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Formula: C27H46O3
Dorweiler I
24)25/h6-11
Flavopiridol is initially found to inhibit the epidermal growth factor receptor and protein kinase A (IC50 = 21 and 122 μM)
InChiKey: BJSDNVVWJYDOLK-UHFFFAOYSA-N
SB-705498 - CAS# 501951-42-4 ine (hydrochloride monohydrate) Formula: C27H46O3SB 705498 is an orally bioavailable, competitive antagonist of the capsaicin mediated activation of TRPV1 receptors (pKis = 7. 6, 7. 5, and 7. 3 for human, rat, and guinea pig, respectively). SB 705498 inhibits the capsaicin , acid , and heat mediated activation of the receptor. SB 705498 was shown to be a potent competitive antagonist of the capsaicin mediated activation of the human TRPV1 receptor (pK(i) = 7. 6) with activity at rat (pK(i) = 7. 5)
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