PRT-060318 zelnidipine D7 Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(N)=O

Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(N)=O

Biomol Ther (Seoul)

Solubility: DMSO : 125 mg/mL (495

but has minimal effect on viability of nontransformed human cells

PubMed PMID: 26223815

PRT-060318 zelnidipine D7 Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(N)=OPRT 060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM. Product information CAS Number: 1194961 19 7 Molecular Weight: 340. 42 Formula: C18H24N6O Chemical Name: 2 {[(1R,2S) 2 aminocyclohexyl]amino} 4 [(3 methylphenyl)amino]pyrimidine 5 carboxamide Smiles: CC1=CC(=CC=C1)NC1=NC(N[C@@H]2CCCC[C@@H]2N)=NC=C1C(N)=O InChiKey: NZNTWOVDIXCHHS LSDHHAIUSA N InChi: InChI=1S C18H24N6O c1 11 5 4 6 12(9 11)22 17