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SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid and vascular regrowth contribute toSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low