![AZD 5153 Catalog No.:M22444-C Chemical Name: (2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M22444_1635324323.gif?v=1635324326)
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Chemical Name: (2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1
CAS Number: 150399-21-6
026 and P<0
Formula: C8H14ClN5O4
InChi: InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2
AZD 5153 Catalog No.:M22444-C Chemical Name: (2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1Target: BRD4 IC50: 5 nM AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET) protein BRD4, with the IC50 value of 5 nM. AZD5153 could simultaneously ligate two bromodomains in BRD4, and exert antitumor activity in multiple xenograft tumor models . In Vitro: A quantitative immuno fluorescent assay in U2OS cells revealed that AZD5153 could significantly disrupt BRD4 foci, with the IC50 value of 1. 7