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Scheuermann TH
radiosensitizing
De Brabander J
Berlinicke C
2 mL/min/kg
mpi-0479605 - CAS# 1246529-32-7 size:2mg solid Scheuermann THMPI 0479605, CAS No. 1246529 32 7, is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI 0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM and RAD3 related dependent activation of the p53 p21 pathway. In both wild type and p53 mutant cells lines, there is a growth arrest and
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