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CDK2/cyclin A (IC50 = 680 nM)
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
Paulsen JE
10(3):318-323
and it is a powerful inhibitor of kinases other than CK2
SSR128129E - CAS# 848318-25-2 272 CDK2/cyclin A (IC50 = 680SSR128129E (SSR), CAS No. 848318 25 2, is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and
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