X-NeuNAc Size:Solid 10 mg KRCA-0008 is a potent dual

KRCA-0008 is a potent dual inhibitor of Ack1 and anaplastic lymphoma kinase (ALK)

Formula: C19H18N2O4S

significant inhibition of tumor growth is seen at doses ≥6 mg/kg/day (60% inhibition in mice and 98% inhibition in rats versus animals treated with vehicle) and

2020 Sep 14

Evaluation in mouse

X-NeuNAc Size:Solid 10 mg KRCA-0008 is a potent dualX NeuNAc, also known as CB1339 and X Neu5Ac, is a novel substrate for chromogenic assay of neuraminidase activity in bacterial expression systems. X NeuNAc can be used to facilitate the screening of bacterial colonies or plaques for the detection of either natural or mutant neuraminidase activity. Preliminary kinetic studies indicate that this compound is a good substrate (Km 0. 89 x 10( 3) M) for neuraminidase and is quite stable under identical